After a major cold epidemic sweeps through the office, the Pointy-Haired Boss tasks Dilbert with designing a new building, capable of supporting the various mutations the employees are experiencing.
Dilbert takes a sick to from work, much to the annoyance of Dogbert, who thinks a cold means he can still go to work. He gives Dilbert a placebo, but Dilbert refuses, saying he's close to curing the common cold. However, his machine explodes, and he opts for the placebo instead.
At work, he, Alice, and Wally are working on The Gruntmaster 6000, but Alice and Wally are to sick to work, and Dilbert keeps spraying air freshener and anti-bacteriants to of a can.